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<p></p><p>Enantiomerically pure pyrrolidine derivatives, incorporating a pharmacologically relevant asymmetric center and diverse substituents, were synthesized from (<i>S</i>)-proline. Comprehensive characterization (NMR, HRMS, FTIR, ECD, X-ray) and <i>in silico</i> ADMET (SwissADME) analysis revealed favorable physicochemical properties and drug-likeness for the majority of the compounds. Key structural modifications significantly impacted lipophilicity and solubility. Molecular docking studies revealed promising binding affinities toward a specific target (Ras:SOS complex), highlighting the compounds' potential for drug development. Further biological evaluation is necessary to fully assess their pharmacological activity.</p>

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Synthesis of chiral pyrrolidine derivatives with promising pharmacological activity

  • 期刊论文

  • 发表日期：

    2025年4月1日

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  • Tigran H. Yeganyan,
  • Astghik A. Shahkhatuni,
  • Andranik M. Davinyan,
  • Harutyun A. Karapetyan,
  • Armen S. Galstyan

摘要

Enantiomerically pure pyrrolidine derivatives, incorporating a pharmacologically relevant asymmetric center and diverse substituents, were synthesized from (S)-proline. Comprehensive characterization (NMR, HRMS, FTIR, ECD, X-ray) and in silico ADMET (SwissADME) analysis revealed favorable physicochemical properties and drug-likeness for the majority of the compounds. Key structural modifications significantly impacted lipophilicity and solubility. Molecular docking studies revealed promising binding affinities toward a specific target (Ras:SOS complex), highlighting the compounds' potential for drug development. Further biological evaluation is necessary to fully assess their pharmacological activity.