<p>Soil, a critical ecosystem component, is vital in maintaining planetary and human health. However, climate change disrupts soil health, leading to increased erosion, reduced fertility, and altered microbial communities, resulting in far-reaching consequences for human health, including malnutrition, exposure to environmental toxins, and infectious diseases. Degraded soils reduce agricultural productivity and lower the nutritional quality of crops, which contributes to malnutrition, particularly in vulnerable populations. Additional risks include exposure to environmental toxins and the spread of infectious diseases. This review explores the interconnected challenges between climate change, soil health, and human well-being, and emphasizes the need for integrated strategies that simultaneously address ecosystem resilience and public health protection. Strategies to improve soil health, reduce antibiotic resistance, and promote sustainable agricultural practices address this global crisis, offering potential benefits such as increased food security and improved public health. Key measures include the use of organic amendments, crop rotation, reduced tillage, and antibiotic stewardship. These efforts are essential for safeguarding human health and ensuring sustainable development in the face of ongoing climate challenges. Our analysis identified a set of key strategies that can enhance soil health, mitigate antibiotic resistance, and promote sustainable agricultural practices. These include the application of organic amendments, implementation of crop rotation, adoption of reduced tillage, and enforcement of antibiotic stewardship measures. Collectively, these approaches offer tangible benefits such as improved food security and public health outcomes. The findings underscore the importance of integrated management practices for ensuring both ecosystem resilience and sustainable development amid the escalating pressures of climate change.</p>