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<p>This review examined adverse childhood experiences (ACEs) associated with the risk of major depressive disorder (MDD) and treatment-resistant depression (TRD). A search was conducted in PubMed, Scopus, PsycINFO, SciELO, and LILACS. Study selection, data extraction, and quality assessment were performed independently by two reviewers. Twenty-four studies were included, encompassing 1,119,606 participants. Family structure adversities and sexual and physical abuse were the most frequently examined exposures, although their associations with MDD varied across studies. Emotional abuse, domestic violence, and bullying were less commonly assessed but showed more consistent associations with MDD. Evidence regarding TRD was limited, with childhood neglect as a risk factor for poorer treatment response. Greater cumulative exposure to ACEs was associated with higher risk of MDD and TRD. Overall, the findings support childhood adversity as a clinically relevant determinant of depressive risk and clinical course, although heterogeneity across study designs and high risk of bias limit causal inference.</p>

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The Role of Adverse Childhood Experiences in the Development of Major Depressive Disorder and Treatment-Resistant Depression

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月21日

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  • Marília Aparecida Batista Dos Santos,
  • Ana Elisa Palha Guerra,
  • Marcella Monteiro Alvarenga Sayão,
  • Ana Luiza da Silva Selani,
  • Beatriz Cristina Betarelli,
  • Izabelle de Faria Siqueira,
  • Marcela Forgerini

摘要

This review examined adverse childhood experiences (ACEs) associated with the risk of major depressive disorder (MDD) and treatment-resistant depression (TRD). A search was conducted in PubMed, Scopus, PsycINFO, SciELO, and LILACS. Study selection, data extraction, and quality assessment were performed independently by two reviewers. Twenty-four studies were included, encompassing 1,119,606 participants. Family structure adversities and sexual and physical abuse were the most frequently examined exposures, although their associations with MDD varied across studies. Emotional abuse, domestic violence, and bullying were less commonly assessed but showed more consistent associations with MDD. Evidence regarding TRD was limited, with childhood neglect as a risk factor for poorer treatment response. Greater cumulative exposure to ACEs was associated with higher risk of MDD and TRD. Overall, the findings support childhood adversity as a clinically relevant determinant of depressive risk and clinical course, although heterogeneity across study designs and high risk of bias limit causal inference.