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<p>Arginine methylation, catalyzed by protein arginine methyltransferases (PRMTs), is a regulatory key mechanism involved in various cellular processes such as gene expression, RNA processing, DNA damage repair. Increasing evidence highlights the crucial role of PRMTs in human diseases, including cancer, cardiovascular and metabolic diseases. Here, this review focuses on the latest findings regarding PRMTs in the central nervous system (CNS), emphasizing their regulatory roles in neural stem cells, neurons, and glial cells. Additionally, we examine the connection between PRMTs dysregulation and neurological diseases affecting the CNS, including brain tumors, neurodegenerative diseases, and neurodevelopmental disorders. Therefore, this review aims to deepen our understanding of PRMTs-mediated arginine methylation in CNS and open avenues for developing novel therapeutic strategies for neurological diseases.</p> Graphical Abstract <p>PRMTs’ role in neural cells and neurological diseases in CNS. PRMTs-mediated arginine methylation plays a significant role in multiple biological processes of neural cells via regulating protein–protein and protein-RNA interactions, such as NSC proliferation and differentiation, neuron morphogenesis and activity, glial cells development and function. Its dysregulation is closely linked to neurological diseases in CNS including brain tumors, neurodegenerative diseases, and neurodevelopmental disorders.</p> <p></p>

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Protein Arginine Methyltransferases from Regulatory Function to Clinical Implication in Central Nervous System

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月14日

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  • Bin Xie,
  • Jing Yu,
  • Chao Chen,
  • Ting Shen

摘要

Arginine methylation, catalyzed by protein arginine methyltransferases (PRMTs), is a regulatory key mechanism involved in various cellular processes such as gene expression, RNA processing, DNA damage repair. Increasing evidence highlights the crucial role of PRMTs in human diseases, including cancer, cardiovascular and metabolic diseases. Here, this review focuses on the latest findings regarding PRMTs in the central nervous system (CNS), emphasizing their regulatory roles in neural stem cells, neurons, and glial cells. Additionally, we examine the connection between PRMTs dysregulation and neurological diseases affecting the CNS, including brain tumors, neurodegenerative diseases, and neurodevelopmental disorders. Therefore, this review aims to deepen our understanding of PRMTs-mediated arginine methylation in CNS and open avenues for developing novel therapeutic strategies for neurological diseases.

Graphical Abstract

PRMTs’ role in neural cells and neurological diseases in CNS. PRMTs-mediated arginine methylation plays a significant role in multiple biological processes of neural cells via regulating protein–protein and protein-RNA interactions, such as NSC proliferation and differentiation, neuron morphogenesis and activity, glial cells development and function. Its dysregulation is closely linked to neurological diseases in CNS including brain tumors, neurodegenerative diseases, and neurodevelopmental disorders.