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<p>Electrospun dressings have emerged as a cutting-edge solution in advanced wound care. This research examines the creation of an innovative nanofibrous structure combining polyvinyl alcohol (PVA) and chitosan (CS) in the presence of Zn–Al layered double hydroxide (Zn–Al LDH) nanoparticles incorporated with <i>Scrophularia striata</i> extract (SSE). The integration of SSE-laden nanoparticles significantly bolstered the physical and mechanical characteristics of the resulting mats. Remarkably, all specimens exhibited fiber diameters below 350&#xa0;nm. The mats demonstrated excellent hydrophilicity, with water contact angles spanning 36 ± 2–71 ± 1° and water uptake percentages ranging from 254 ± 8 to 340 ± 6%. The specimen with the highest nanoparticle concentration displayed peak tensile strength at 4.0 ± 0.2&#xa0;MPa and the greatest elongation at the break of 39.04%. In vitro evaluations, including MTT and scratch assays, disclosed no cytotoxicity in the prepared mats. Instead, they facilitated HDF cell migration, proliferation, and viability. Additional assessments confirmed the Fickian release of SSE (<InlineEquation ID="IEq1"> <EquationSource Format="TEX">\(\text{n }&lt; 0.45\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mtext>n</mtext> <mspace width="0.333333em" /> <mo>&lt;</mo> <mn>0.45</mn> </mrow> </math></EquationSource> </InlineEquation>) and the antibacterial and antioxidant properties of the mats. These results suggest that the designed electrospun mats safeguard the wound bed and excellently mimic the natural extracellular matrix, potentially expediting the healing process.</p>

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Chitosan-based electrospun wound dressings containing Scrophularia striata extract and layered double hydroxide nanoparticles (LDH-NPs)

  • 期刊论文

  • 发表日期：

    2026年5月3日

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  • Mahsa Salemi,
  • Parvaneh Maghami,
  • Reza Hosseinzadeh,
  • Fattah Sotoodehnejadnematalahi

摘要

Electrospun dressings have emerged as a cutting-edge solution in advanced wound care. This research examines the creation of an innovative nanofibrous structure combining polyvinyl alcohol (PVA) and chitosan (CS) in the presence of Zn–Al layered double hydroxide (Zn–Al LDH) nanoparticles incorporated with Scrophularia striata extract (SSE). The integration of SSE-laden nanoparticles significantly bolstered the physical and mechanical characteristics of the resulting mats. Remarkably, all specimens exhibited fiber diameters below 350 nm. The mats demonstrated excellent hydrophilicity, with water contact angles spanning 36 ± 2–71 ± 1° and water uptake percentages ranging from 254 ± 8 to 340 ± 6%. The specimen with the highest nanoparticle concentration displayed peak tensile strength at 4.0 ± 0.2 MPa and the greatest elongation at the break of 39.04%. In vitro evaluations, including MTT and scratch assays, disclosed no cytotoxicity in the prepared mats. Instead, they facilitated HDF cell migration, proliferation, and viability. Additional assessments confirmed the Fickian release of SSE ( \(\text{n }< 0.45\) n < 0.45 ) and the antibacterial and antioxidant properties of the mats. These results suggest that the designed electrospun mats safeguard the wound bed and excellently mimic the natural extracellular matrix, potentially expediting the healing process.