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<p>Addressing the critical clinical challenge of achieving simultaneous rapid hemostasis and infection prevention in deep, narrow, and irregular non-compressible wounds, this study developed a composite hemostatic sponge using natural mushroom as the substrate. Through alkali treatment to preserve its native polysaccharide 3D network, followed by TEMPO-mediated oxidation and in situ synthesis of ZIF-8 nanoparticles, we constructed a biomaterial featuring a highly interconnected microporous structure that enables remarkable 3&#xa0;s shape recovery upon hydration. The incorporated ZIF-8 nanocrystals demonstrate dual functionality—significantly accelerating the coagulation cascade while exhibiting potent antibacterial activity against both <i>E. coli</i> and <i>S. aureus</i> pathogens. In vivo evaluation using a rat liver penetrating injury model revealed significantly enhanced hemostatic performance compared to commercial gelatin sponges and Celox™. Comprehensive biosafety assessments confirmed excellent cytocompatibility and hemocompatibility. These combined properties including rapid hemostasis, antimicrobial efficacy, and biocompatibility position ZIF-8@OAM as a promising next-generation multifunctional hemostatic agent for clinical applications.</p> Graphic abstract <p></p>

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ZIF-8 functionalized polysaccharide-based mushroom with water-triggered shape memory and antibacterial activity for noncompressible bleeding control

  • 期刊论文

  • 发表日期：

    2026年1月3日

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  • Mingdong Yan,
  • Ruimin Liu,
  • Wenting Jiang,
  • Changfu Xie,
  • Weiliang Wu,
  • Linyu Xu

摘要

Addressing the critical clinical challenge of achieving simultaneous rapid hemostasis and infection prevention in deep, narrow, and irregular non-compressible wounds, this study developed a composite hemostatic sponge using natural mushroom as the substrate. Through alkali treatment to preserve its native polysaccharide 3D network, followed by TEMPO-mediated oxidation and in situ synthesis of ZIF-8 nanoparticles, we constructed a biomaterial featuring a highly interconnected microporous structure that enables remarkable 3 s shape recovery upon hydration. The incorporated ZIF-8 nanocrystals demonstrate dual functionality—significantly accelerating the coagulation cascade while exhibiting potent antibacterial activity against both E. coli and S. aureus pathogens. In vivo evaluation using a rat liver penetrating injury model revealed significantly enhanced hemostatic performance compared to commercial gelatin sponges and Celox™. Comprehensive biosafety assessments confirmed excellent cytocompatibility and hemocompatibility. These combined properties including rapid hemostasis, antimicrobial efficacy, and biocompatibility position ZIF-8@OAM as a promising next-generation multifunctional hemostatic agent for clinical applications.

Graphic abstract