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<p>Cellulose nanocrystals (CNCs) have outstanding mechanical properties and biocompatibility, making them highly suitable for a variety of applications. However, unmodified CNCs tend to aggregate, leading to suspension instability and limited practical use. In this study, CNCs were modified by silanization (A174) and then cross-linked with acrylamide (AM) to create a CNC-A174-PAM-PB hydrogel encapsulating polymyxin B sulfate (PB), which responds to a weak alkaline reaction. The modified CNCs and resulted hydrogel were characterized by using Fourier transform infrared spectrometer (FT-IR), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), thermal gravimetric analyzer (TGA), transmission electron microscope (TEM), etc. These modifications significantly enhanced the dispersibility and thermal stability of CNCs. The hydrogel exhibited excellent swelling capacity and drug release properties in the weakly alkaline environments, as well as potent antibacterial effects against&#xa0;<i>Escherichia coli</i> (<i>E. coli</i>)&#xa0;and&#xa0;<i>Staphylococcus aureus</i> (<i>S. aureus</i>). In vivo experiments indicated that the CNC-A174-PAM-PB hydrogel effectively accelerated wound healing on the SD rat skin defect model. The CNC-A174-PAM-PB hydrogel shows a promising application in wound healing with bacterial infection. </p> Graphical abstract <p></p>

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Preparation of a cellulose nanocrystal-based hydrogel for wound healing and the antimicrobial properties

  • 期刊论文

  • 发表日期：

    2025年5月5日

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  • Xinyu Lin,
  • Yingfan Xia,
  • Lipei Miao,
  • Weike Su,
  • Qihong Zhang

摘要

Cellulose nanocrystals (CNCs) have outstanding mechanical properties and biocompatibility, making them highly suitable for a variety of applications. However, unmodified CNCs tend to aggregate, leading to suspension instability and limited practical use. In this study, CNCs were modified by silanization (A174) and then cross-linked with acrylamide (AM) to create a CNC-A174-PAM-PB hydrogel encapsulating polymyxin B sulfate (PB), which responds to a weak alkaline reaction. The modified CNCs and resulted hydrogel were characterized by using Fourier transform infrared spectrometer (FT-IR), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), thermal gravimetric analyzer (TGA), transmission electron microscope (TEM), etc. These modifications significantly enhanced the dispersibility and thermal stability of CNCs. The hydrogel exhibited excellent swelling capacity and drug release properties in the weakly alkaline environments, as well as potent antibacterial effects against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). In vivo experiments indicated that the CNC-A174-PAM-PB hydrogel effectively accelerated wound healing on the SD rat skin defect model. The CNC-A174-PAM-PB hydrogel shows a promising application in wound healing with bacterial infection.

Graphical abstract