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<p>Abnormal embryonic development leads to the formation of cleft palate (CP) which is difficult to be detected by genetic screening and needs sequent treatment from infants to adults. There are no interceptive treatment about CP until now. Germline deletion of phosphatase and tensin homolog (<i>Pten</i>) was related to embryonic malformation and regulated tumor cell proliferation through glycolysis. However, the role of <i>Pten</i> in CP and the relationship between CP, <i>Pten,</i> and glycolysis are unknown. In our research, we constructed <i>Pten</i> knockdown models in vitro and in vivo. Our results provided preliminary evidence that blocking <i>Pten</i> by its inhibitor such as VO-OHpic might be an effective interceptive treatment in early period of palate development when pregnant mother expose in harmful environment during the early period of palate development to reducing CP occurring which was related with the crosstalk between <i>Pten</i>, and glycolysis in the process.</p> Graphical Abstract <p></p>

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Glycolysis regulates palatal mesenchyme proliferation through Pten-Glut1 axis via Pten classical and non-classical pathways

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月27日

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  • Yijia Wang,
  • Xia Peng,
  • Xiaotong Wang,
  • Jing Chen,
  • Xiaoyu Zheng,
  • Xige Zhao,
  • Cui Guo,
  • Juan Du

摘要

Abnormal embryonic development leads to the formation of cleft palate (CP) which is difficult to be detected by genetic screening and needs sequent treatment from infants to adults. There are no interceptive treatment about CP until now. Germline deletion of phosphatase and tensin homolog (Pten) was related to embryonic malformation and regulated tumor cell proliferation through glycolysis. However, the role of Pten in CP and the relationship between CP, Pten, and glycolysis are unknown. In our research, we constructed Pten knockdown models in vitro and in vivo. Our results provided preliminary evidence that blocking Pten by its inhibitor such as VO-OHpic might be an effective interceptive treatment in early period of palate development when pregnant mother expose in harmful environment during the early period of palate development to reducing CP occurring which was related with the crosstalk between Pten, and glycolysis in the process.

Graphical Abstract