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<p>A green and efficient method has been developed for the synthesis of chromene analogues via atom-economical heterocyclization. This methodology enables ultrarapid and sustainable synthesis of heterocyclic analogues, without generating byproducts and multiple reuse cycles of the nanocatalyst. This process involves the reaction of different aldehydes, 4-hydroxycoumarin, and malononitrile in water using 8-hydroxyquinoline-5-sulfonic acid@CoFe<sub>2</sub>O<sub>4</sub> (HQS@CoFe<sub>2</sub>O<sub>4</sub>) as a magnetic catalyst under mild reaction conditions (70&#xa0;°C). The procedure offers several advantages, including operational simplicity, high yields (97%), short reaction times, and no need for laborious purification steps. The catalyst demonstrates excellent activity in aqueous media and its easy preparation and straightforward magnetic separation make it a practical and effective heterogeneous system. Notably, the catalyst can be reused multiple times with minimal loss of performance. The synthesized chromene analogues were characterized by melting point, IR, and ¹H NMR spectroscopy, confirming their successful formation.</p> <b>Graphical Abstract</b> <p></p>

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One-Pot Multicomponent Synthesis of Chromene Analogues by HQS@CoFe2O4 Nanocatalyst

  • 期刊论文

  • 发表日期：

    2025年10月3日

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  • K. S. Patil,
  • S. T. Mane,
  • D. M. Sirsat,
  • D. G. Kanase

摘要

A green and efficient method has been developed for the synthesis of chromene analogues via atom-economical heterocyclization. This methodology enables ultrarapid and sustainable synthesis of heterocyclic analogues, without generating byproducts and multiple reuse cycles of the nanocatalyst. This process involves the reaction of different aldehydes, 4-hydroxycoumarin, and malononitrile in water using 8-hydroxyquinoline-5-sulfonic acid@CoFe2O4 (HQS@CoFe2O4) as a magnetic catalyst under mild reaction conditions (70 °C). The procedure offers several advantages, including operational simplicity, high yields (97%), short reaction times, and no need for laborious purification steps. The catalyst demonstrates excellent activity in aqueous media and its easy preparation and straightforward magnetic separation make it a practical and effective heterogeneous system. Notably, the catalyst can be reused multiple times with minimal loss of performance. The synthesized chromene analogues were characterized by melting point, IR, and ¹H NMR spectroscopy, confirming their successful formation.

Graphical Abstract