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<p>The selective oxidation of Ethylbenzene to acetophenone is a crucial transformation in organic synthesis, as acetophenone is a key intermediate in the production of pharmaceuticals, fragrances, and fine chemicals. This study focuses on developing an efficient heterogeneous catalyst for this oxidation reaction under mild reaction conditions. Mesoporous MCM-48 was prepared using the hydrothermal method, yielding a high surface area and a well-ordered pore structure that enhances catalytic efficiency. This catalyst exhibited excellent catalytic activity, achieving 98% conversion and 97% selectivity for acetophenone using TBHP as a mild oxidant. To improve its performance, several reaction parameters were changed, such as temperature, catalyst loading, reaction duration, and oxidant concentration. Furthermore, the catalyst demonstrated high stability and reusability, retaining its activity over multiple cycles. The essential role of the Co(II) active site in promoting selective oxidation is highlighted by a proposed reaction mechanism. This work underscores the potential of mesoporous material-supported cobalt catalysts as highly active, air-stable, and reusable alternatives for sustainable organic transformations.</p> Graphical Abstract <p></p>

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Design and Catalytic Activity of a Cobalt(II) Acylpyrazolone Complex Anchored on MCM-48 for Selective Ethylbenzene Oxidation

  • 期刊论文

  • 发表日期：

    2025年6月10日

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  • Grishma Vala,
  • Rajendrasinh N. Jadeja,
  • Aditya A. Puranik,
  • Ray J. Butcher

摘要

The selective oxidation of Ethylbenzene to acetophenone is a crucial transformation in organic synthesis, as acetophenone is a key intermediate in the production of pharmaceuticals, fragrances, and fine chemicals. This study focuses on developing an efficient heterogeneous catalyst for this oxidation reaction under mild reaction conditions. Mesoporous MCM-48 was prepared using the hydrothermal method, yielding a high surface area and a well-ordered pore structure that enhances catalytic efficiency. This catalyst exhibited excellent catalytic activity, achieving 98% conversion and 97% selectivity for acetophenone using TBHP as a mild oxidant. To improve its performance, several reaction parameters were changed, such as temperature, catalyst loading, reaction duration, and oxidant concentration. Furthermore, the catalyst demonstrated high stability and reusability, retaining its activity over multiple cycles. The essential role of the Co(II) active site in promoting selective oxidation is highlighted by a proposed reaction mechanism. This work underscores the potential of mesoporous material-supported cobalt catalysts as highly active, air-stable, and reusable alternatives for sustainable organic transformations.

Graphical Abstract