Scholarlink

<p>Since&#xa0;quinolin-4(1H)-one derivatives are very important in medicinal chemistry due to their unique structure and diverse biological properties, the development of new methods and catalytic systems for the synthesizing of&#xa0;these compounds is of great importance. In this regard, we presented an attractive, general, applicable, green, and efficient procedure for preparing various derivatives of quinoline-4(1H)-ones, in which palladium nanocomposite [Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>-Diol-Phen-Pd(0)] was used as a reusable magnetic catalyst. Three-component reactions of various derivatives of heteroaryl alkynes reacted well with nitrobenzene, and Cr(CO)<sub>6</sub> was well catalyzed by Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>-Diol-Phen-Pd(0) nanocomposite using KOAc in water/PEG and the desired quinoline-4 (1H)-one derivative were afforded with very satisfactory results. The water played a very important role in this reaction because it made the nitro functional group easily convert to the amine group, and the reaction was carried out more efficiently. With respect to the previous methods that have been reported, this method is superior to other methods due to the significant features. The synthesis of products can achieve higher yields when reactions are performed in a water/PEG solvent system within a timeframe of under two hours. This catalytic system is versatile and can be applied to a broad spectrum of substrates. Additionally, it allows for easy separation of the catalyst from the reaction mixture, ensuring high reusability of the catalyst for multiple cycles.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Research on Ecofriendly Synthesis of Quinolin-4(1H)-Ones Using Fe3O4@SiO2-Diol-Phen-Pd(0) Nanocomposites as a Novel and Reusable Catalyst: Catalysis in Carbonylative Cyclization Reactions

  • 期刊论文

  • 发表日期：

    2025年1月3日

查看全文
  • Ahmed M. Amshawee,
  • Radwan Ali,
  • Maryam A. Hussain,
  • Mosstafa Kazemi

摘要

Since quinolin-4(1H)-one derivatives are very important in medicinal chemistry due to their unique structure and diverse biological properties, the development of new methods and catalytic systems for the synthesizing of these compounds is of great importance. In this regard, we presented an attractive, general, applicable, green, and efficient procedure for preparing various derivatives of quinoline-4(1H)-ones, in which palladium nanocomposite [Fe3O4@SiO2-Diol-Phen-Pd(0)] was used as a reusable magnetic catalyst. Three-component reactions of various derivatives of heteroaryl alkynes reacted well with nitrobenzene, and Cr(CO)6 was well catalyzed by Fe3O4@SiO2-Diol-Phen-Pd(0) nanocomposite using KOAc in water/PEG and the desired quinoline-4 (1H)-one derivative were afforded with very satisfactory results. The water played a very important role in this reaction because it made the nitro functional group easily convert to the amine group, and the reaction was carried out more efficiently. With respect to the previous methods that have been reported, this method is superior to other methods due to the significant features. The synthesis of products can achieve higher yields when reactions are performed in a water/PEG solvent system within a timeframe of under two hours. This catalytic system is versatile and can be applied to a broad spectrum of substrates. Additionally, it allows for easy separation of the catalyst from the reaction mixture, ensuring high reusability of the catalyst for multiple cycles.

Graphical Abstract