<p>Burn injuries cause significant damage to the skin and underlying tissues. This damage can lead to life-threatening complications due to the loss of the body’s natural protective barrier. In severe cases, doctors often treat burns by surgically removing dead tissue and performing skin grafts, usually along with antibiotic therapy. However, burn wounds are very vulnerable to infection. <i>Pseudomonas aeruginosa</i> is one of the most common germs found in burn wound infections. Its growing resistance to antibiotics, especially in hospitals, creates a major challenge for treatment. Mesenchymal stromal cells (MSCs) have emerged as a promising option for managing burn wounds. Besides their ability to promote healing, MSCs can also regulate the immune response and fight infections. At the injury site, MSCs manage inflammation, encourage the growth of new blood vessels, and aid tissue repair through signaling molecules like growth factors, cytokines, and chemokines. Additionally, MSCs help the immune system by releasing antimicrobial peptides and proteins (AMPs) and by boosting the activity of immune cells such as phagocytes. This review elucidates the therapeutic potential of MSCs in managing burn wound infections caused by <i>P. aeruginosa</i>. By synthesizing findings from recent studies, it underscores the multifaceted role of MSCs in combating <i>P. aeruginosa</i> infections through their antibacterial, antibiofilm, and regenerative properties, offering a promising approach to address the challenges of antibiotic-resistant burn wounds.</p>