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<p>Head and neck squamous cell carcinoma (HNSCC) exhibits significant survival disparities by ancestry. This review explores how genetic ancestry shapes the clinical and molecular features of HNSCC, providing insights into the molecular mechanisms underlying these disparities. We reveal the variation in gene expression, mutations, copy number alterations, and DNA methylation patterns between ancestral groups. These insights highlight the potential for more personalized, ancestry-informed therapies, advancing equity in cancer treatment.</p>

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The impact of genomic ancestry on tumor genomics in head and neck squamous cell carcinoma

  • 期刊论文

  • 发表日期：

    2026年1月30日

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  • Madeleine Ndahayo,
  • Anirudh Saxena,
  • Hannah Thomas,
  • Kathryn Hughes Barry,
  • Daria A. Gaykalova

摘要

Head and neck squamous cell carcinoma (HNSCC) exhibits significant survival disparities by ancestry. This review explores how genetic ancestry shapes the clinical and molecular features of HNSCC, providing insights into the molecular mechanisms underlying these disparities. We reveal the variation in gene expression, mutations, copy number alterations, and DNA methylation patterns between ancestral groups. These insights highlight the potential for more personalized, ancestry-informed therapies, advancing equity in cancer treatment.