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<p>During the last three decades, there has been substantial advancement in comprehending the chemical attributes and roles of natural killer (NK) cells, resulting in a growing interest in these cells. Simultaneously, the swift advancement of adoptive transfer therapy for immune cells, particularly the impressive achievements of autologous chimeric antigen receptor-T (CAR-T) cells in treating hematological malignant tumors, has fueled interest in using immune cells as a cancer treatment modality and opened the door for NK cell adoptive immunotherapy. NK cell-mediated immunotherapy has shown potential as a readily available, safe, and effective treatment for patients with leukemia. Moreover, clinical studies have demonstrated that NK cell adoptive immunotherapy shows efficacy in various solid tumors and hematologic malignancies, indicating a promising future for this therapeutic approach. This paper will provide an overview of NK cell adoptive therapy, focusing on current clinical trial results and the challenges associated with clinical applications.</p>

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Prospects and limitations of NK cell adoptive therapy in clinical applications

  • 期刊论文

  • 发表日期：

    2025年6月25日

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  • Yamin Deng,
  • Chen Wu,
  • Jintong Na,
  • Jing Tang,
  • Simin Qin,
  • Zhiyong Zhang,
  • Liping Zhong

摘要

During the last three decades, there has been substantial advancement in comprehending the chemical attributes and roles of natural killer (NK) cells, resulting in a growing interest in these cells. Simultaneously, the swift advancement of adoptive transfer therapy for immune cells, particularly the impressive achievements of autologous chimeric antigen receptor-T (CAR-T) cells in treating hematological malignant tumors, has fueled interest in using immune cells as a cancer treatment modality and opened the door for NK cell adoptive immunotherapy. NK cell-mediated immunotherapy has shown potential as a readily available, safe, and effective treatment for patients with leukemia. Moreover, clinical studies have demonstrated that NK cell adoptive immunotherapy shows efficacy in various solid tumors and hematologic malignancies, indicating a promising future for this therapeutic approach. This paper will provide an overview of NK cell adoptive therapy, focusing on current clinical trial results and the challenges associated with clinical applications.