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<p>To compare image quality, agreement in left atrial fibrosis (LAF) quantification, and acquisition time for late gadolinium enhancement (LGE) imaging between three-dimensional whole-heart modified Dixon (mDixon) and phase-sensitive inversion recovery (PSIR) sequences of cardiac magnetic resonance (CMR) in patients with atrial fibrillation (AF). Thirty patients with AF who underwent LGE-CMR were prospectively enrolled. Subjective image quality scores, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), contrast ratio (CR), and acquisition time were compared, and inter-sequence agreement in LAF quantification was assessed. Compared with PSIR-LGE, mDixon-LGE achieved a higher rate of excellent image quality (80% vs. 60%, <i>P</i> = 0.031), higher CNR<sub>LGE-blood pool</sub> (41.50 ± 21.92 vs. 18.10 ± 6.65, <i>P</i> &lt; 0.001), and higher CR<sub>LGE–blood pool</sub> (0.22 ± 0.11 vs. 0.11 ± 0.04, <i>P</i> &lt; 0.001). Bland–Altman analysis demonstrated good agreement between mDixon-LGE and PSIR-LGE for total LAF (bias: − 0.36%; 95% LoA: − 10.58% to 9.84%), interstitial LAF (bias: 0.15%; 95% LoA: −6.20% to 6.50%), and dense LAF (bias: −0.52%; 95% LoA: −6.67% to 5.62%). The mDixon-LGE acquisition time (6.7 ± 2.4&#xa0;min) was significantly shorter than that of PSIR-LGE (9.0 ± 2.7&#xa0;min, <i>P</i> &lt; 0.001). mDixon-LGE and PSIR-LGE demonstrated good agreement in quantifying LAF in patients with AF. mDixon-LGE showed a higher proportion of excellent image quality ratings, higher measured LGE-to-blood pool contrast values, and shorter acquisition time, supporting its use as a technically feasible and time-efficient alternative for LAF assessment.</p>

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Quantitative detection of left atrial fibrosis in patients with atrial fibrillation: a comparative study of two 3D whole-heart late gadolinium enhancement sequences

  • 期刊论文

  • 发表日期：

    2026年3月9日

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  • Jia-Shen Jiang,
  • Qi Xu,
  • Si-Si Zhu,
  • Liu-Mei Li,
  • Xiao-Yu Wang,
  • Lei Li,
  • Kou-Long Zheng,
  • Xi-Wu Ruan,
  • Sheng Huang,
  • Tian-Le Wang,
  • Rong-Xing Qi

摘要

To compare image quality, agreement in left atrial fibrosis (LAF) quantification, and acquisition time for late gadolinium enhancement (LGE) imaging between three-dimensional whole-heart modified Dixon (mDixon) and phase-sensitive inversion recovery (PSIR) sequences of cardiac magnetic resonance (CMR) in patients with atrial fibrillation (AF). Thirty patients with AF who underwent LGE-CMR were prospectively enrolled. Subjective image quality scores, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), contrast ratio (CR), and acquisition time were compared, and inter-sequence agreement in LAF quantification was assessed. Compared with PSIR-LGE, mDixon-LGE achieved a higher rate of excellent image quality (80% vs. 60%, P = 0.031), higher CNRLGE-blood pool (41.50 ± 21.92 vs. 18.10 ± 6.65, P < 0.001), and higher CRLGE–blood pool (0.22 ± 0.11 vs. 0.11 ± 0.04, P < 0.001). Bland–Altman analysis demonstrated good agreement between mDixon-LGE and PSIR-LGE for total LAF (bias: − 0.36%; 95% LoA: − 10.58% to 9.84%), interstitial LAF (bias: 0.15%; 95% LoA: −6.20% to 6.50%), and dense LAF (bias: −0.52%; 95% LoA: −6.67% to 5.62%). The mDixon-LGE acquisition time (6.7 ± 2.4 min) was significantly shorter than that of PSIR-LGE (9.0 ± 2.7 min, P < 0.001). mDixon-LGE and PSIR-LGE demonstrated good agreement in quantifying LAF in patients with AF. mDixon-LGE showed a higher proportion of excellent image quality ratings, higher measured LGE-to-blood pool contrast values, and shorter acquisition time, supporting its use as a technically feasible and time-efficient alternative for LAF assessment.