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<p>Adverse cardiac events such as heart failure and death may occur in hypertrophic cardiomyopathy (HCM) patients, and myocardial strain enables early assessment of myocardial contractility and cardiac function, whereas the prognostic value of cardiac magnetic resonance (CMR)-derived myocardial strain in HCM is not known about. Therefore, the aim of this study is to discuss the prognostic value of myocardia strain by CMR in HCM patients. The included articles were obtained from PubMed, Embase, Web of Science, and Cochrane Library databases up to September 30, 2024; NOS Scale was used to assess the methodological quality of eligible studies; study endpoints mainly consisted of primary endpoint and secondary endpoint, and hazard ratio (HR) and 95% confidence interval (CI) were used to evaluate relationship between CMR- derived myocardia strain and the prognosis of HCM patients; in addition, subgroup and sensitivity analyses were performed. Twelve studies were finally included. CMR-derived myocardial strain was significantly associated with primary and secondary endpoint in HCM patients, with pooled HRs of 1.23 [95% CI (1.10,1.38), <i>P</i> = 0.0003] and 1.62 [95% CI (1.14,2.31), <i>P</i> = 0.007], respectively. In subgroup analysis, the primary endpoint of 3.0T MRI, tissue tracking method, and left ventricular position were more significant, with pooled HRs of 1.39 [95% CI (1.15,1.68)], 5.71 [95% CI (1.66,19.69)], and 1.39 [95% CI (1.13,1.71)], respectively. Myocardial strain based on CMR is significantly associated with adverse cardiac events in HCM patients, but caution is needed in interpreting the results because of the large heterogeneity between studies.</p>

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Prognostic value of CMR-derived myocardial strain in hypertrophic cardiomyopathy: a systematic review and meta-analysis

  • 期刊论文

  • 发表日期：

    2026年1月28日

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  • Liang Cao,
  • Chengke Wei,
  • Rui Li,
  • Feng Liu,
  • Shunlin Guo

摘要

Adverse cardiac events such as heart failure and death may occur in hypertrophic cardiomyopathy (HCM) patients, and myocardial strain enables early assessment of myocardial contractility and cardiac function, whereas the prognostic value of cardiac magnetic resonance (CMR)-derived myocardial strain in HCM is not known about. Therefore, the aim of this study is to discuss the prognostic value of myocardia strain by CMR in HCM patients. The included articles were obtained from PubMed, Embase, Web of Science, and Cochrane Library databases up to September 30, 2024; NOS Scale was used to assess the methodological quality of eligible studies; study endpoints mainly consisted of primary endpoint and secondary endpoint, and hazard ratio (HR) and 95% confidence interval (CI) were used to evaluate relationship between CMR- derived myocardia strain and the prognosis of HCM patients; in addition, subgroup and sensitivity analyses were performed. Twelve studies were finally included. CMR-derived myocardial strain was significantly associated with primary and secondary endpoint in HCM patients, with pooled HRs of 1.23 [95% CI (1.10,1.38), P = 0.0003] and 1.62 [95% CI (1.14,2.31), P = 0.007], respectively. In subgroup analysis, the primary endpoint of 3.0T MRI, tissue tracking method, and left ventricular position were more significant, with pooled HRs of 1.39 [95% CI (1.15,1.68)], 5.71 [95% CI (1.66,19.69)], and 1.39 [95% CI (1.13,1.71)], respectively. Myocardial strain based on CMR is significantly associated with adverse cardiac events in HCM patients, but caution is needed in interpreting the results because of the large heterogeneity between studies.