Scholarlink

Abstract <p>The British Cardiovascular Intervention Society Jeopardy Score (BCIS-JS) is an established, simplified scoring system for assessing coronary artery disease (CAD) extensiveness with excellent agreement between the invasive and the computed tomography (CT) angiography-based scores. Originally developed for use during invasive coronary angiography, it supports procedural planning and risk stratification by estimating the extent of myocardium at risk. The computed tomography (CT)-based version (CT-BCIS-JS) has shown excellent agreement with the invasive score. We aimed to investigate the value of the CT-BCIS-JS in predicting long-term outcomes. This retrospective single-center study included 337 patients referred for coronary CT angiography (CCTA). CT-BCIS-JS was calculated using a purpose-developed online calculator, and patients were divided into extensive and non-extensive CAD (BCIS ≥ 6 and BCIS &lt; 6, respectively). The primary outcome was the composite of all-cause death and nonfatal myocardial infarction (MI) and the secondary outcome was major adverse cardiovascular events (MACEs), including all-cause mortality, MI, unstable angina requiring hospitalization, and coronary revascularization. Kaplan-Meier curves and multivariable-Cox regression analyses were utilized to compare outcomes between groups. Of the 337 patients, 249 (73.9%) patients had BCIS-JS &lt; 6 and 88 (26.1%) patients had BCIS-JS ≥ 6. Overall, the primary outcome occurred in 47 (13.9%) patients over a median follow-up of 6.8 years (interquartile range 5.7–8.5 years). Thirthy-eight of them (43.2%) had BCIS-JS ≥ 6 compared to 9 (3.6%) in the BCIS-JS &lt; 6 group (adjusted hazard ratio [aHR]: 11.15; 95% CI 4.97–24.99; <i>p</i> &lt; 0.001). The secondary outcome occurred in 77 patients (87.5%) who had BCIS-JS ≥ 6 compared to 20 (8.0%) in the BCIS-JS &lt; 6 group (aHR: 19.92; 95% CI: 11.40-34.81; <i>p</i> &lt; 0.001). CT-BCIS-JS allows excellent risk stratification in patients with known or suspected CAD. Anatomically extensive CAD identified with the CT-BCIS-JS is a strong predictor of higher mortality, nonfatal MI, and MACE.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Assessing extensive coronary artery disease using a myocardial jeopardy score based on coronary CT: long-term prognostic value

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月17日

查看全文
  • Andreas A. Giannopoulos,
  • Alexia Rossi,
  • Dimitrios V. Moysidis,
  • Jan A. Schaab,
  • Stjepan Jurisic,
  • Tobia Albertini,
  • Alessandro Candreva,
  • Barbara E. Stähli,
  • Dominik C. Benz,
  • Ronny R. Buechel,
  • Philipp A. Kaufmann,
  • Aju P. Pazhenkottil

摘要

Abstract

The British Cardiovascular Intervention Society Jeopardy Score (BCIS-JS) is an established, simplified scoring system for assessing coronary artery disease (CAD) extensiveness with excellent agreement between the invasive and the computed tomography (CT) angiography-based scores. Originally developed for use during invasive coronary angiography, it supports procedural planning and risk stratification by estimating the extent of myocardium at risk. The computed tomography (CT)-based version (CT-BCIS-JS) has shown excellent agreement with the invasive score. We aimed to investigate the value of the CT-BCIS-JS in predicting long-term outcomes. This retrospective single-center study included 337 patients referred for coronary CT angiography (CCTA). CT-BCIS-JS was calculated using a purpose-developed online calculator, and patients were divided into extensive and non-extensive CAD (BCIS ≥ 6 and BCIS < 6, respectively). The primary outcome was the composite of all-cause death and nonfatal myocardial infarction (MI) and the secondary outcome was major adverse cardiovascular events (MACEs), including all-cause mortality, MI, unstable angina requiring hospitalization, and coronary revascularization. Kaplan-Meier curves and multivariable-Cox regression analyses were utilized to compare outcomes between groups. Of the 337 patients, 249 (73.9%) patients had BCIS-JS < 6 and 88 (26.1%) patients had BCIS-JS ≥ 6. Overall, the primary outcome occurred in 47 (13.9%) patients over a median follow-up of 6.8 years (interquartile range 5.7–8.5 years). Thirthy-eight of them (43.2%) had BCIS-JS ≥ 6 compared to 9 (3.6%) in the BCIS-JS < 6 group (adjusted hazard ratio [aHR]: 11.15; 95% CI 4.97–24.99; p < 0.001). The secondary outcome occurred in 77 patients (87.5%) who had BCIS-JS ≥ 6 compared to 20 (8.0%) in the BCIS-JS < 6 group (aHR: 19.92; 95% CI: 11.40-34.81; p < 0.001). CT-BCIS-JS allows excellent risk stratification in patients with known or suspected CAD. Anatomically extensive CAD identified with the CT-BCIS-JS is a strong predictor of higher mortality, nonfatal MI, and MACE.

Graphical abstract