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Purpose <p>Excess body fat increases endometrial cancer risk, and moderate-to-vigorous physical activity (MVPA) lowers risk, but the relationship between post-diagnosis MVPA, walking, sedentary time (SED), and endometrial cancer survival is under-researched.</p> Methods <p>Cancer Prevention Study-II participants self-reported post-diagnosis MVPA (MET hour/week, h/wk), walking (h/wk), and SED (h/wk). Meeting MVPA guidelines was defined as 7.5 to &lt;15 MET h/wk. Walking was categorized as 0, &lt;2, 2–6, or &gt;6&#xa0;h/wk. SED was divided into tertiles (T1–T3). Hazard ratios and 95% confidence intervals (HR, CI) are calculated using delayed-entry Cox models, adjusted for covariates.</p> Results <p>We identified 1016 endometrial cancer survivors (mean BMI: 27.6, age at diagnosis: 72&#xa0;years, 97% White, 71% college educated, 93% married). Over an average 13.5&#xa0;years of follow-up, 511 deaths occurred (232 any cancer, 60 endometrial cancer). Compared to no MVPA, associations were not statistically significant, but point estimates suggest that higher amounts of MVPA [measured on average 1.2-year post-diagnosis] are potentially associated with lower all-cause mortality risk [doubling guidelines (HR: 0.71, 95% CI 0.50, 1.00)] but not total cancer mortality risk. Walking &lt;2&#xa0;h/wk was associated with higher all-cause mortality risk compared to no walking (HR: 1.45, 95% CI: 1.08, 1.96) but not cancer mortality risk. Limiting SED was not associated with survival.</p> Conclusion <p>This study suggests that higher amounts of MVPA may be associated with survival among older endometrial cancer survivors; however, further research is needed in larger/pooled cohorts with more cancer deaths.</p>

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Every move matters: physical activity, walking, sedentary behavior, and endometrial cancer survival

  • 期刊论文

  • 发表日期：

    2025年8月26日

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  • Lauren C. Bates-Fraser,
  • Matthew Masters,
  • Clara Bodelon,
  • Lauren E. McCullough,
  • Marissa M. Shams-White,
  • Alpa V. Patel,
  • Erika Rees-Punia

摘要

Purpose

Excess body fat increases endometrial cancer risk, and moderate-to-vigorous physical activity (MVPA) lowers risk, but the relationship between post-diagnosis MVPA, walking, sedentary time (SED), and endometrial cancer survival is under-researched.

Methods

Cancer Prevention Study-II participants self-reported post-diagnosis MVPA (MET hour/week, h/wk), walking (h/wk), and SED (h/wk). Meeting MVPA guidelines was defined as 7.5 to <15 MET h/wk. Walking was categorized as 0, <2, 2–6, or >6 h/wk. SED was divided into tertiles (T1–T3). Hazard ratios and 95% confidence intervals (HR, CI) are calculated using delayed-entry Cox models, adjusted for covariates.

Results

We identified 1016 endometrial cancer survivors (mean BMI: 27.6, age at diagnosis: 72 years, 97% White, 71% college educated, 93% married). Over an average 13.5 years of follow-up, 511 deaths occurred (232 any cancer, 60 endometrial cancer). Compared to no MVPA, associations were not statistically significant, but point estimates suggest that higher amounts of MVPA [measured on average 1.2-year post-diagnosis] are potentially associated with lower all-cause mortality risk [doubling guidelines (HR: 0.71, 95% CI 0.50, 1.00)] but not total cancer mortality risk. Walking <2 h/wk was associated with higher all-cause mortality risk compared to no walking (HR: 1.45, 95% CI: 1.08, 1.96) but not cancer mortality risk. Limiting SED was not associated with survival.

Conclusion

This study suggests that higher amounts of MVPA may be associated with survival among older endometrial cancer survivors; however, further research is needed in larger/pooled cohorts with more cancer deaths.