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Purpose <p>Few studies have explored whether accelerometer-measured sedentary behavior increases cancer risk. We examined the associations of accelerometer-measured daily sitting time and mean sitting bout duration classified by the Convolutional Neural Network Hip Accelerometer Posture (CHAP) machine-learned algorithm with incidence of any cancer, incidence of 13 physical activity-related cancers, and cancer mortality among postmenopausal women.</p> Methods <p>We used data from 22,097 women (mean age = 73.3&#xa0;years, standard deviation [SD] = 6.7) in the Women’s Health Accelerometry Collaboration, a consortium of two US-based cohort studies of postmenopausal women: the Women’s Health Study and the Women’s Health Initiative Objective Physical Activity and Cardiovascular Health Study. Women who completed hip-worn triaxial accelerometry for ≥ 4 of 7 consecutive days were included. Associations between sedentary behaviors and physician-adjudicated invasive cancer incidence and mortality were tested using Cox regression.</p> Results <p>Women were followed on average 8.0&#xa0;years to identify cancer cases (<i>n</i> = 1,861) and deaths (<i>n</i> = 601). Overall, mean sitting time was 567 (SD = 113) min/day and mean sitting bout duration was 12.8 (SD = 4) min/bout. In covariate-adjusted models, one-SD increment higher in sitting time was associated with a 6% increased risk of incident cancer (hazard ratio [HR] = 1.06, 95% CI: 1.01–1.11); associations were similar for bout duration (HR = 1.05, 95% CI: 1.00–1.10). Estimates were similar for the 13 physical activity-related cancers (sitting time: HR = 1.10, 95% CI: 1.04–1.17; bout duration: HR = 1.08, 95% CI: 1.02–1.14) and for cancer mortality (sitting time: 1.06, 95% CI: 0.98–1.16; bout duration: HR = 1.05, 95% CI: 0.97–1.13).</p> Conclusion <p>Among postmenopausal women, sedentary behavior was associated with increased cancer risk, particularly for physical activity-related cancers and cancer mortality.</p>

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Sitting time and risk of cancer incidence and cancer mortality in postmenopausal women: the Women’s Health Accelerometry Collaboration

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月2日

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  • Eric T. Hyde,
  • Kelly R. Evenson,
  • Annie Green Howard,
  • Humberto Parada, Jr.,
  • Chongzhi Di,
  • Michael J. LaMonte,
  • John Bellettiere,
  • Carmen C. Cuthbertson,
  • I-Min Lee,
  • Andrea Z. LaCroix

摘要

Purpose

Few studies have explored whether accelerometer-measured sedentary behavior increases cancer risk. We examined the associations of accelerometer-measured daily sitting time and mean sitting bout duration classified by the Convolutional Neural Network Hip Accelerometer Posture (CHAP) machine-learned algorithm with incidence of any cancer, incidence of 13 physical activity-related cancers, and cancer mortality among postmenopausal women.

Methods

We used data from 22,097 women (mean age = 73.3 years, standard deviation [SD] = 6.7) in the Women’s Health Accelerometry Collaboration, a consortium of two US-based cohort studies of postmenopausal women: the Women’s Health Study and the Women’s Health Initiative Objective Physical Activity and Cardiovascular Health Study. Women who completed hip-worn triaxial accelerometry for ≥ 4 of 7 consecutive days were included. Associations between sedentary behaviors and physician-adjudicated invasive cancer incidence and mortality were tested using Cox regression.

Results

Women were followed on average 8.0 years to identify cancer cases (n = 1,861) and deaths (n = 601). Overall, mean sitting time was 567 (SD = 113) min/day and mean sitting bout duration was 12.8 (SD = 4) min/bout. In covariate-adjusted models, one-SD increment higher in sitting time was associated with a 6% increased risk of incident cancer (hazard ratio [HR] = 1.06, 95% CI: 1.01–1.11); associations were similar for bout duration (HR = 1.05, 95% CI: 1.00–1.10). Estimates were similar for the 13 physical activity-related cancers (sitting time: HR = 1.10, 95% CI: 1.04–1.17; bout duration: HR = 1.08, 95% CI: 1.02–1.14) and for cancer mortality (sitting time: 1.06, 95% CI: 0.98–1.16; bout duration: HR = 1.05, 95% CI: 0.97–1.13).

Conclusion

Among postmenopausal women, sedentary behavior was associated with increased cancer risk, particularly for physical activity-related cancers and cancer mortality.