<p>AI has already generated transformative effects across domains of business and everyday life. However, the integration of AI into the scholarship of disability entrepreneurship remains nascent. One critical challenge is the difficulty to identify what constitutes a theoretically distinct effect of AI on disabled entrepreneurs and corresponding entrepreneurial processes, as opposed to merely exploring its use among a marginalized group. To address this issue, the present study systematically analyzes how AI uniquely affects disability entrepreneurs. On this basis, the paper proposes a preliminary theoretical model of disability entrepreneurship in the AI era that examines both the positive and negative impacts of AI on disabled entrepreneurs, as well as the ethical dilemmas that arise from these dynamics. It then outlines a set of theoretically meaningful and practically relevant research opportunities that bridge the literatures on AI and disability entrepreneurship. By doing so, this paper positions disability entrepreneurship as a theoretically significant research domain in the AI era, advances discussions of ethical dilemmas related to AI, and offers a systematic framework for guiding future theoretical and empirical research.</p>