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Purpose <p>To evaluate the potential prognostic value of two peripheral immune biomarkers—neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII)—in breast cancer patients treated with neoadjuvant chemotherapy, and to assess their association with pathological complete response (pCR) and other predictive factors. In addition, to determine whether prognostic or predictive differences exist between baseline and post-neoadjuvant values of these biomarkers.</p> Methods <p>We analyzed 801 women with early breast cancer treated with neoadjuvant chemotherapy, evaluating clinical and pathological data, survival outcomes, NLR (continuous and categorical) and SII.</p> Results <p>Baseline NLR was significantly higher in younger patients, in those with positive pathological nodes, and in the HER2 + /HR − subtype, while baseline SII was elevated in the triple-negative subtype. Post-neoadjuvant chemotherapy (post-NCT) NLR and SII showed only weak associations with estrogen receptor expression, yet both were independently associated with pCR (post-NCT NLR: OR = 0.91; 95% CI: 0.84–0.98; <i>p</i> = 0.02; post-NCT SII: OR = 0.65; 95% CI: 0.47–0.89; <i>p</i> = 0.008). Neither biomarker showed a significant impact on overall or progression-free survival.</p> Conclusion <p>Post-treatment NLR and SII may reflect chemotherapy-induced immune changes and are associated with pathological complete response, but their additional predictive value is uncertain, and no prognostic impact was observed.</p>

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Unlocking the predictive value of post-neoadjuvant immune biomarkers in breast cancer: neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII)

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月16日

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  • María Esperanza Guirao García,
  • Pedro Marín Rodríguez,
  • Carmen María Servet Pérez de Lema,
  • Noel Blaya Boluda,
  • Pilar Sánchez Henarejos,
  • Miguel Ángel Moya Hernández,
  • Andrea Gottlob Pérez,
  • Caridad Marín Hernández,
  • Pilar de la Morena Barrio,
  • Elisa García Garre,
  • Elena García-Martínez,
  • Francisco Ayala de la Peña,
  • Antonio Piñero Madrona,
  • Esmeralda García-Torralba

摘要

Purpose

To evaluate the potential prognostic value of two peripheral immune biomarkers—neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII)—in breast cancer patients treated with neoadjuvant chemotherapy, and to assess their association with pathological complete response (pCR) and other predictive factors. In addition, to determine whether prognostic or predictive differences exist between baseline and post-neoadjuvant values of these biomarkers.

Methods

We analyzed 801 women with early breast cancer treated with neoadjuvant chemotherapy, evaluating clinical and pathological data, survival outcomes, NLR (continuous and categorical) and SII.

Results

Baseline NLR was significantly higher in younger patients, in those with positive pathological nodes, and in the HER2 + /HR − subtype, while baseline SII was elevated in the triple-negative subtype. Post-neoadjuvant chemotherapy (post-NCT) NLR and SII showed only weak associations with estrogen receptor expression, yet both were independently associated with pCR (post-NCT NLR: OR = 0.91; 95% CI: 0.84–0.98; p = 0.02; post-NCT SII: OR = 0.65; 95% CI: 0.47–0.89; p = 0.008). Neither biomarker showed a significant impact on overall or progression-free survival.

Conclusion

Post-treatment NLR and SII may reflect chemotherapy-induced immune changes and are associated with pathological complete response, but their additional predictive value is uncertain, and no prognostic impact was observed.