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Purpose <p>This study aims to evaluate the impact of lymph node status on survival outcomes in female breast cancer patients underwent immediate breast reconstruction (IBR) after mastectomy.</p> Methods <p>Data from 8418 cases (2010–2017) receiving IBR were divided into regional lymph node negative (LN−) and positive (LN+) groups. Propensity score matching (PSM) was used to balance covariates between groups. Subgroup Cox regression analysis was performed to assess overall survival (OS) and breast cancer-specific survival (BCSS), considering sociodemographic, oncological, and treatment-related factors.</p> Results <p>Inpatients underwent IBR, the LN+  group exhibited significantly poorer OS and BCSS than the LN− group, both before and after PSM. Higher income, specific tumor characteristics, and implant-based reconstruction were related to better survival outcomes. Subgroup analysis revealed that in LN− group, lower income, HR−, HER2− status, and higher tumor grade were OS/BCSS risk factors. In the LN+  group, advanced T stage independently predicted worse OS/BCSS, and contralateral breast removal was associated with a decrease in OS risk.</p> Conclusions <p>Caution is warranted when recommending IBR for patients with N2–3, and implant-based reconstruction may represent a more favorable option in selected cases. LN+  status is a significant adverse prognostic factor in IBR patients. Personalized treatment strategies based on LN status are essential for optimizing survival outcomes.</p>

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Impact of lymph node status on the prognosis of female breast cancer patients who underwent immediate reconstruction after total mastectomy: a multi-institutional retrospective cohort study

  • 期刊论文

  • 发表日期：

    2025年11月21日

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  • Qianrui Xu,
  • Xinyan Li,
  • Xiehui Deng,
  • Miaosi Li,
  • Xiangyun Zong

摘要

Purpose

This study aims to evaluate the impact of lymph node status on survival outcomes in female breast cancer patients underwent immediate breast reconstruction (IBR) after mastectomy.

Methods

Data from 8418 cases (2010–2017) receiving IBR were divided into regional lymph node negative (LN−) and positive (LN+) groups. Propensity score matching (PSM) was used to balance covariates between groups. Subgroup Cox regression analysis was performed to assess overall survival (OS) and breast cancer-specific survival (BCSS), considering sociodemographic, oncological, and treatment-related factors.

Results

Inpatients underwent IBR, the LN+  group exhibited significantly poorer OS and BCSS than the LN− group, both before and after PSM. Higher income, specific tumor characteristics, and implant-based reconstruction were related to better survival outcomes. Subgroup analysis revealed that in LN− group, lower income, HR−, HER2− status, and higher tumor grade were OS/BCSS risk factors. In the LN+  group, advanced T stage independently predicted worse OS/BCSS, and contralateral breast removal was associated with a decrease in OS risk.

Conclusions

Caution is warranted when recommending IBR for patients with N2–3, and implant-based reconstruction may represent a more favorable option in selected cases. LN+  status is a significant adverse prognostic factor in IBR patients. Personalized treatment strategies based on LN status are essential for optimizing survival outcomes.