<p>The process of blood oxygenation through photocatalytic action is an emerging concept in the realm of artificial lung technology, differing from current technologies that rely on the oxygenation of blood via permeable hollow fibers. This novel method necessitates the use of a semiconductor and an appropriate light source. When blood interacts with a semiconductor in the presence of light, it produces dissolved oxygen directly from the water found in the blood. In this study, we introduce a photocatalyst referred to as surface modified TiO₂ nanotubes combined with Ti₃C₂T_x MXene. Initially, TiO₂ nanotubes were fabricated using an electrochemical anodization process. Following this, Ti₃C₂T_x flakes were applied to the surface of the TNTs through a chemical bath technique. The Ti₃C₂T_x-TNTs samples were characterized using X-ray diffraction (XRD), field emission scanning electron microscope (FE-SEM), High-Resolution Transmission Electron Microscope (HRTEM), and X-ray photoelectron spectroscope (XPS). The hemolysis activity was evaluated to assess the biocompatibility of the produced samples. In terms of blood oxygenation, the Ti₃C₂T_x-TNTs are simply placed in contact with blood and then exposed to a UV lamp to initiate the photocatalytic reaction. Optical absorption studies on diluted blood demonstrate a significant enhancement in blood oxygenation. The absorption value at 415&#xa0;nm, which corresponds to the oxyhemoglobin peak, shows a relative increase in oxygenation values from 2.08 (bare TNTs) to 2.84 (Ti₃C₂T_x-TNTs), significantly due to the formation of a Schottky barrier between MXene and TNTs. This positive change is also reflected in the standard hemoglobin test, with levels increasing from 16.7 (bare TNTs) to 17.9&#xa0;g/dL (Ti₃C₂T_x-TNTs). An examination of the structure of red blood cells was conducted using an optical microscope, and it was observed that there was no occurrence of hemolysis after the photocatalytic process.</p>