Scholarlink

<p>Microneedles with porous internal structures can provide pathways for transdermal ionic current and drug delivery by penetrating the stratum corneum of the skin. However, conventional porous microneedle arrays are typically monolithic and rigid, limiting their flexibility and adaptability to curved skin surfaces. To address the issue, a method to directly integrate an array of porous microneedles to a flexible substrate is proposed, preserving their skin penetration capability while enhancing flexibility. The resulting array conforms to curved skin surfaces while effectively reducing transdermal ionic resistance. Numerical and analytical modeling demonstrates that the limited number of needles on a flexible array is sufficient to reduce transdermal resistance. Further, an enzymatic battery is combined to create a fully organic, porous microneedle-based bioelectric skin patch that can generate stable transdermal current suitable for stimulation and drug delivery applications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Flexible porous microneedle array for bioelectric skin patch

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月10日

查看全文
  • Soichiro Tottori,
  • Mirai Matsuura,
  • Sae Ichinose,
  • Haechang Cho,
  • Tarryn Galloway,
  • Natsuho Moriyama,
  • Matsuhiko Nishizawa

摘要

Microneedles with porous internal structures can provide pathways for transdermal ionic current and drug delivery by penetrating the stratum corneum of the skin. However, conventional porous microneedle arrays are typically monolithic and rigid, limiting their flexibility and adaptability to curved skin surfaces. To address the issue, a method to directly integrate an array of porous microneedles to a flexible substrate is proposed, preserving their skin penetration capability while enhancing flexibility. The resulting array conforms to curved skin surfaces while effectively reducing transdermal ionic resistance. Numerical and analytical modeling demonstrates that the limited number of needles on a flexible array is sufficient to reduce transdermal resistance. Further, an enzymatic battery is combined to create a fully organic, porous microneedle-based bioelectric skin patch that can generate stable transdermal current suitable for stimulation and drug delivery applications.