<p>Understanding the different distribution patterns of biodiversity is essential for the development of conservation strategies. This theme has become extremely relevant, especially due to the current context of climate change. The genus <i>Frullania</i> belongs to the group of liverworts and has a wide diversity of species in the world and in Brazil. This genus can be a potential indicator for understanding the diversity patterns of liverworts in Brazil and can be used in the process of selecting key areas for conservation since it represents one of the largest genera of liverworts in the country. Therefore, we analyzed the distribution patterns of <i>Frullania</i> in Brazil. The results indicate that areas near the northeastern, southeastern, and southern coastline exhibit greatest species richness and endemism, overlapping with the range of the Atlantic Forest. The distribution of the genus is influenced by temperature seasonality, mean temperature of the coldest quarter, and precipitation of the coldest quarter. Through this study, we were able to point out the areas with greater richness and endemism of <i>Frullania</i> in Brazil and indicate areas that need to be considered in conservation plans.</p>