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<p>Plant molecular farming (PMF) has emerged as a promising strategy for producing biopharmaceuticals and high‐value biomolecules in plant systems. In this review, we present a comprehensive synthesis of current methodologies while introducing novel approaches to genetic transformation, protein expression, glycan engineering, and downstream processing. We offer in‐depth analyses of recent advancements such as CRISPR/Cas9‐mediated pathway editing, synthetic biology frameworks for optimizing protein yield and quality, and integrated bioprocessing solutions that enhance purification efficiency. Further, detailed case studies are discussed to illustrate actionable strategies, and future research directions are proposed to bridge current gaps. By focusing on transformative techniques and critical problem‐solving perspectives, this review aims to guide researchers toward more effective and scalable PMF applications.</p>

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Advancing the frontier of plant-based therapeutics: critical innovations in molecular farming and bioprocess Integration

  • 期刊论文

  • 发表日期：

    2026年3月23日

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  • Kalidas Gowtham,
  • Balamurugan Shanmugaraj,
  • Lohith Saran Thangavel,
  • Aksittha Srinivasan,
  • Ashwini Malla

摘要

Plant molecular farming (PMF) has emerged as a promising strategy for producing biopharmaceuticals and high‐value biomolecules in plant systems. In this review, we present a comprehensive synthesis of current methodologies while introducing novel approaches to genetic transformation, protein expression, glycan engineering, and downstream processing. We offer in‐depth analyses of recent advancements such as CRISPR/Cas9‐mediated pathway editing, synthetic biology frameworks for optimizing protein yield and quality, and integrated bioprocessing solutions that enhance purification efficiency. Further, detailed case studies are discussed to illustrate actionable strategies, and future research directions are proposed to bridge current gaps. By focusing on transformative techniques and critical problem‐solving perspectives, this review aims to guide researchers toward more effective and scalable PMF applications.