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<p>Arthropathies are joint-related disorders with diverse etiologies but standard clinical and radiographic features. There is growing evidence that long non-coding RNAs (lncRNAs) play a crucial role in regulating the development and progression of certain diseases. Nuclear-enriched abundant transcript 1 (NEAT1) is one of these lncRNAs. It is common and helps control transcription and epigenetics, especially during inflammation. This narrative review presents current data on NEAT1’s role in inflammation and its contribution to the development of arthropathies, including psoriasis, rheumatoid arthritis, osteoarthritis, SLE, Behçet’s disease, and hemophilic arthropathy. The research demonstrated that NEAT1 regulates immune cell activity, inflammasome formation, and inflammatory signaling pathways through interactions with miRNAs and transcriptional regulators. The activity, progression, and response to treatment of the disease are all linked to its dysregulated expression. In conclusion, NEAT1 appears to be a significant regulator of inflammation and joint disease, potentially serving as both a therapeutic target and a biomarker for joint-related disorders. More mechanistic and translational studies are needed to better understand how it works and how it might be used in medicine.</p>

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The Impact of NEAT1 on Inflammatory Responses and Processes in Arthropathic Diseases: Latest Findings and Perspectives

  • 期刊论文

  • 发表日期：

    2026年2月11日

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  • Suleiman Ibrahim Mohammad,
  • Raed Obaid Saleh,
  • Hamza Abu Owida,
  • Zahraa Abbas Al-Khafaji,
  • Pooja Varma,
  • Asokan Vasudevan,
  • Wesam R. Kadhum,
  • Ahmed Read Al-Tameemi,
  • Yasser Fakri Mustafa,
  • Shakeel Ahmed Ansari

摘要

Arthropathies are joint-related disorders with diverse etiologies but standard clinical and radiographic features. There is growing evidence that long non-coding RNAs (lncRNAs) play a crucial role in regulating the development and progression of certain diseases. Nuclear-enriched abundant transcript 1 (NEAT1) is one of these lncRNAs. It is common and helps control transcription and epigenetics, especially during inflammation. This narrative review presents current data on NEAT1’s role in inflammation and its contribution to the development of arthropathies, including psoriasis, rheumatoid arthritis, osteoarthritis, SLE, Behçet’s disease, and hemophilic arthropathy. The research demonstrated that NEAT1 regulates immune cell activity, inflammasome formation, and inflammatory signaling pathways through interactions with miRNAs and transcriptional regulators. The activity, progression, and response to treatment of the disease are all linked to its dysregulated expression. In conclusion, NEAT1 appears to be a significant regulator of inflammation and joint disease, potentially serving as both a therapeutic target and a biomarker for joint-related disorders. More mechanistic and translational studies are needed to better understand how it works and how it might be used in medicine.