<p>One in 16, 000 live births is affected by the retinal tumor RB (retinoblastoma), which is frequently found in a child’s early years. Both of the RB1 alleles that have been locally mutated in the affected retina are present in 60 percent of cases. Retinoblastoma (RB) can be detected using a variety of techniques, including imaging of the brain and orbits, eye examinations under anesthesia (EUAs), and the discovery of cell-free tumor DNA in samples of aqueous humor or plasma. In addition to the conventional surgical, chemotherapy, and radiotherapy approaches to treating retinoblastoma, new approaches have also been developed. Oncogenes, genes of tumor suppressors, and other molecular elements involved in cell growth and division interact complexly during the pathogenesis of retinoblastoma. The development of new therapies depends on comprehending the function of these molecular components. As a small class of non-coding RNAs capable of altering gene expression, microRNAs (miRNA) are understood to represent potential targets for the treatment of cancer. This study aimed to describe the changes in microRNA expression in some types of cancer, with a particular focus on retinoblastoma.</p> Graphical Abstract <p>Molecular mechanism of microRNA targeting: a promising approach for retinoblastoma diagnosis and treatment. The pathogenesis of retinoblastoma involves a complex interaction between tumor suppressor genes, oncogene, and other molecular components involved in cell growth and division</p> <p></p>