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<p>Modern in vitro studies of neural networks require the integration of electrophysiological methods and high-precision imaging. Despite advances in the development of multielectrode arrays (MEA), issues remain regarding their compatibility with optical methods. This is particularly important for long-term experiments requiring continuous observation of living cells. For these purposes, a&#xa0;biocompatible multielectrode cell creating controlled conditions for cultivating neurons during experiments was developed. This article describes an integrated system compatible with a&#xa0;scanning capillary microscope. The cell developed here ensures parameter stability by means of interconnections between subsystems, i.e., gas and temperature control, along with microfluidic management of buffer solutions.</p>

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A biocompatible multi-electrode cell for the study of neurons using capillary microscopy

  • 期刊论文

  • 发表日期：

    2025年11月19日

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  • O. V. Ivanov,
  • A. I. Akhmetova,
  • G. S. Evtushenko,
  • Yu. L. Rybakov,
  • V. M. Gukasov,
  • V. Yaminskii

摘要

Modern in vitro studies of neural networks require the integration of electrophysiological methods and high-precision imaging. Despite advances in the development of multielectrode arrays (MEA), issues remain regarding their compatibility with optical methods. This is particularly important for long-term experiments requiring continuous observation of living cells. For these purposes, a biocompatible multielectrode cell creating controlled conditions for cultivating neurons during experiments was developed. This article describes an integrated system compatible with a scanning capillary microscope. The cell developed here ensures parameter stability by means of interconnections between subsystems, i.e., gas and temperature control, along with microfluidic management of buffer solutions.