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<p>This report presents studies of the penetrating ability of magnetic liposomes into biological gels using microfluidic analytical systems (MFAS). Magnetic liposomes with an average size of about 200 nm were tested under the influence of a&#xa0;constant magnetic field. Aqueous solutions based on gelatin, polyacrylamide, and agarose were used as model biological gels. Gels were tested by placement in MFAS formed from polymethyl methacrylate by thermocompression bonding and laser ablation methods. The result showed that selection of polymer gel matrixes should take account of the pore size and magnetic nanocarriers used. The results obtained here lead to the conclusion that this approach has potential at the initial stages of developing drugs for personalized and targeted therapy.</p>

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Studies of the penetrating ability of magnetic liposomes into biological gels using microfluidic systems

  • 期刊论文

  • 发表日期：

    2025年3月6日

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  • K. E. Brusina,
  • N. O. Sitkov,
  • K. G. Gareev,
  • A. I. Nikiforov,
  • T. M. Zimina,
  • N. N. Potrakhov,
  • D. V. Korolev

摘要

This report presents studies of the penetrating ability of magnetic liposomes into biological gels using microfluidic analytical systems (MFAS). Magnetic liposomes with an average size of about 200 nm were tested under the influence of a constant magnetic field. Aqueous solutions based on gelatin, polyacrylamide, and agarose were used as model biological gels. Gels were tested by placement in MFAS formed from polymethyl methacrylate by thermocompression bonding and laser ablation methods. The result showed that selection of polymer gel matrixes should take account of the pore size and magnetic nanocarriers used. The results obtained here lead to the conclusion that this approach has potential at the initial stages of developing drugs for personalized and targeted therapy.