<p>As the challenges posed by an aging population become increasingly apparent, the prevention and treatment of age-related diseases have become key research priorities. This study hypothesizes that Zhizi Baipi Decoction exhibits aging modulatory effects. Traditional Chinese Medicine Decoction that has been passed down for generations and remains widely used in contemporary clinical practice. Due to their short lifespan, well-defined genetic backgrounds, and ease of manipulation, model organisms such as <i>Drosophila</i> and <i>C. elegans</i> are commonly employed in aging modulatory research. This study evaluated the aging modulatory potential of Zhizi Baipi Decoction using <i>Drosophila</i> and <i>C. elegans</i> as model organisms, and used a Nuclear Magnetic Resonance-based metabolomics approach to explore the aging modulatory potential of Zhizi Baipi Decoction and its intrinsic mechanism. It was found that Zhizi Baipi Decoction could prolong the lifespan of <i>Drosophila</i> and <i>C. elegans</i>, improve locomotor activity, delay intestinal aging and so on, establishing a foundational framework for the future research and development of this traditional remedy.</p>