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<p>Frailty is a significant health issue among older adults. Oxidative stress (OS), indicated by elevated malondialdehyde (MDA) levels and reduced superoxide dismutase (SOD) activity, is implicated in age-related diseases. This study aims to explore the relationship between OS biomarkers, MDA and SOD, and frailty among older adults. This study investigated the association between MDA, SOD, and frailty in 3181 older adults from the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Frailty was assessed using a 37-variable frailty index. Logistic regression and restricted cubic spline (RCS) analysis were employed to examine the relationship between OS biomarkers and frailty, adjusting for demographic, socioeconomic, lifestyle, and physically relevant factors. This study has found that higher MDA levels were significantly associated with increased frailty risk (OR = 1.06, 95% CI: 1.03–1.09), while SOD activity showed no independent association. The threshold point for MDA was 3.37 (<i>P</i> = 0.003). This study highlights that MDA is independent OS biomarker related to frailty in community-dwelling older adults, suggesting plasma MDA as OS biomarker could potentially aid in the identification and clinical management of frailty.</p>

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Oxidative stress in frailty among older adults: are malondialdehyde and superoxide dismutase the key biomarkers?

  • 期刊论文

  • 发表日期：

    2026年2月12日

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  • Yuyang Zhang,
  • Jiali Zheng,
  • Xiaoxiao Zhang,
  • Yanwen Zhang,
  • Kexin Zhang,
  • Yujiao Hao,
  • Yang Li,
  • Tingting Ma,
  • Xinyu Bai,
  • Yulu Wang,
  • Yaogang Wang,
  • Qi Lu,
  • Yue Zhao

摘要

Frailty is a significant health issue among older adults. Oxidative stress (OS), indicated by elevated malondialdehyde (MDA) levels and reduced superoxide dismutase (SOD) activity, is implicated in age-related diseases. This study aims to explore the relationship between OS biomarkers, MDA and SOD, and frailty among older adults. This study investigated the association between MDA, SOD, and frailty in 3181 older adults from the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Frailty was assessed using a 37-variable frailty index. Logistic regression and restricted cubic spline (RCS) analysis were employed to examine the relationship between OS biomarkers and frailty, adjusting for demographic, socioeconomic, lifestyle, and physically relevant factors. This study has found that higher MDA levels were significantly associated with increased frailty risk (OR = 1.06, 95% CI: 1.03–1.09), while SOD activity showed no independent association. The threshold point for MDA was 3.37 (P = 0.003). This study highlights that MDA is independent OS biomarker related to frailty in community-dwelling older adults, suggesting plasma MDA as OS biomarker could potentially aid in the identification and clinical management of frailty.