<p>In recent years, the significance of seismic resilience in engineering structures has been increasingly emphasized. Among the strategies to enhance the seismic resilience of structures, the prestressed frame has garnered considerable interest from researchers, primarily due to its exceptional characteristics, such as self-centering properties. To improve its energy dissipation capacity, various energy devices have been developed to be integrated into the connections of prestressed frames, aimed at enhancing overall seismic performance. However, these devices, while essential for improving seismic resilience, may present challenges in compatibility with existing structural elements and architectural features of buildings, particularly regarding floor integration. In this paper, the authors perform a performance-based design and comprehensive damage evaluation of prestressed structural frames incorporating end-inserted friction system (EIFS). First, the authors introduce the concept of prestressed frames incorporating EIFS and outline a three-stage performance-based design framework for the system. Then, a numerical model is developed and validated, followed by a case study involving three frames to evaluate the static-dynamic damage performance of the system. Finally, a comparison of prestressed frames considering different energy-dissipating mechanisms is implemented. The results indicate that the system can produce a flag-shaped hysteretic curve and demonstrate a reduced failure risk at the same intensity level. Furthermore, the system shows enhanced safety-reserve capacity, requiring a greater intensity level to achieve the same probability of exceedance. These findings underscore the superior performance of the prestressed frame with EIFS and highlight its benefits in mitigating earthquake risks and promoting earthquake resilience.</p> Graphical Abstract <p></p>