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<p>The level of IL1β secretion in culture of LPS-stimulated CD14<sup>+</sup> monocytes from patients with colorectal cancer was determined. Significant differences in cytokine levels were found in patients with early (15.39 [8.358-25.52] pg/mL) and late (30.33 [16.74-44.20] pg/mL) stages of the disease (<i>p</i> = 0.0381). We also revealed a drastic stage-dependent increase in the response to the first stimulation: by 1.6 times in stage I and by 9 times in stage IV (<i>p</i> = 0.023).</p>

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Features of IL-1β Secretion by Macrophages in Monocyte Culture in Colorectal Cancer

  • 期刊论文

  • 发表日期：

    2026年7月27日

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  • N. K. Sadykhov,
  • N. K. Shakhpazyan,
  • L. M. Mikhaleva,
  • A. L. Bedzhanyan,
  • A. A. Bumbazhay,
  • A. K. Konyukova,
  • A. S. Kontorshchikov,
  • K. S. Maslenkina

摘要

The level of IL1β secretion in culture of LPS-stimulated CD14+ monocytes from patients with colorectal cancer was determined. Significant differences in cytokine levels were found in patients with early (15.39 [8.358-25.52] pg/mL) and late (30.33 [16.74-44.20] pg/mL) stages of the disease (p = 0.0381). We also revealed a drastic stage-dependent increase in the response to the first stimulation: by 1.6 times in stage I and by 9 times in stage IV (p = 0.023).