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<p>A positive effect of sleeve gastrectomy on the structural and functional characteristics of the left ventricular myocardium in rats with normal body weight and post-infarction CHF was demonstrated. Sleeve gastrectomy attenuated the upregulated myocardial expression of the <i>Trpc6</i> and <i>Tgfb1</i> genes involved in the pathogenesis of myocardial infarction. These findings attest to a reduction of the negative effects of post-infarction cardiac remodeling.</p>

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Sleeve Gastrectomy Effect on Structural and Functional Myocardium Characteristics and Trpc3, Trpc6, Tgfb1, and Atp2a2 Gene Expression in Rats with Post-Infarction Heart Failure

  • 期刊论文

  • 发表日期：

    2026年7月29日

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  • V. I. Pan,
  • O. V. Kornyushin,
  • T. A. Lelyavina,
  • D. O. Sonin,
  • A. S. Polozov,
  • Yu. V. Cheburkin,
  • P. A. Kapustina,
  • E. A. Zaytseva,
  • Ya. G. Toropova,
  • K. V. Derkach,
  • A. O. Shpakov,
  • M. M. Galagudza

摘要

A positive effect of sleeve gastrectomy on the structural and functional characteristics of the left ventricular myocardium in rats with normal body weight and post-infarction CHF was demonstrated. Sleeve gastrectomy attenuated the upregulated myocardial expression of the Trpc6 and Tgfb1 genes involved in the pathogenesis of myocardial infarction. These findings attest to a reduction of the negative effects of post-infarction cardiac remodeling.