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<p>The present study aimed to investigate a “double-hit” model of Parkinson’s disease, implying intranigral administration of lactacystin and intraperitoneal injection of LPS. The model group rats exhibited significant deterioration in several parameters of the motor function (<i>p</i> ⩽ 0.04) and emotional impairment (<i>p</i> ⩽ 0.04) compared to the control. Morphological signs of neurodegeneration (<i>p</i> ⩽ 0.001) and microglial activation (<i>p</i> ⩽ 0.02) were observed in the substantia nigra. These findings support the utility of this “double-hit” model for elucidating the mechanisms underlying parkinsonism and for preclinical testing of candidate therapeutics.</p>

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The “Double-Hit” Model in Experimental Parkinsonism: Effects of Combined Exposure to Lactacystin and LPS

  • 期刊论文

  • 发表日期：

    2026年7月28日

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  • A. V. Stavrovskaya,
  • A. A. Gerasimov,
  • D. N. Voronkov,
  • A. S. Romanenko,
  • A. S. Olshanskiy,
  • A. K. Pavlova,
  • S. N. Illarioshkin

摘要

The present study aimed to investigate a “double-hit” model of Parkinson’s disease, implying intranigral administration of lactacystin and intraperitoneal injection of LPS. The model group rats exhibited significant deterioration in several parameters of the motor function (p ⩽ 0.04) and emotional impairment (p ⩽ 0.04) compared to the control. Morphological signs of neurodegeneration (p ⩽ 0.001) and microglial activation (p ⩽ 0.02) were observed in the substantia nigra. These findings support the utility of this “double-hit” model for elucidating the mechanisms underlying parkinsonism and for preclinical testing of candidate therapeutics.