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<p>Following a single, severe hypoxic exposure (7000 m, 1 h), changes in the expression levels of <i>Hif1a</i>, <i>Epas1</i> (<i>Hif2a</i>), and <i>Hif3a</i> mRNA, as well as <i>miR-210, miR-107, miR-145, and miR-155</i> microRNAs in peripheral blood leukocytes were assessed in hypoxia-tolerant (HT) and hypoxia-susceptible (HS) male Wistar rats. HT animals exhibited a significant 148% increase in <i>Epas1</i> expression, and HS animals demonstrated a 142% increase in <i>Hif3a</i> expression. Reduced expression levels of <i>rno-miR-210-3p</i>, <i>rno-miR-145-3p</i>, and <i>rno-miR-155-3p</i> in HT rats and increased expression of <i>rno-miR-107-5p</i> in HS rats were also detected. These differences confirm previous data obtained in <i>in vitro</i> and <i>in vivo</i> experiments and indicate a more pronounced adaptive response to oxygen deficiency in HS animals.</p>

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Changes in the Expression Levels of Hypoxia-Inducible Factor Isoforms and Their Regulating microRNAs in Peripheral Blood Leukocytes after Hypoxic Exposure in Wistar Rats with Different Tolerance to Oxygen Deficiency

  • 期刊论文

  • 发表日期：

    2026年6月2日

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  • M. V. Kirillova,
  • D. Sh. Dzhalilova,
  • O. V. Makarova

摘要

Following a single, severe hypoxic exposure (7000 m, 1 h), changes in the expression levels of Hif1a, Epas1 (Hif2a), and Hif3a mRNA, as well as miR-210, miR-107, miR-145, and miR-155 microRNAs in peripheral blood leukocytes were assessed in hypoxia-tolerant (HT) and hypoxia-susceptible (HS) male Wistar rats. HT animals exhibited a significant 148% increase in Epas1 expression, and HS animals demonstrated a 142% increase in Hif3a expression. Reduced expression levels of rno-miR-210-3p, rno-miR-145-3p, and rno-miR-155-3p in HT rats and increased expression of rno-miR-107-5p in HS rats were also detected. These differences confirm previous data obtained in in vitro and in vivo experiments and indicate a more pronounced adaptive response to oxygen deficiency in HS animals.