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<p>The aim of the study was to evaluate the biological activity of a new type of cardioprotectors, activators of Nrf2, based on pyridoxine and fumaric acid derivatives <i>in vitro</i> and <i>in vivo</i>. It was found that di(3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridinium) fumarate is an effective activator of Nrf2 transcription factor and exhibits cytoprotective and antioxidant activity <i>in vitro</i> on a cardiomyocyte model. In addition, this compound reduces the cardiotoxic effect of doxorubicin <i>in vivo</i> by suppressing the development of oxidative processes and activating the Nrf2-dependent antioxidant response in the heart. The studied pyridoxine and fumaric acid derivative has high potential as a candidate medication for reducing the side effects of anthracycline antibiotics, as well as for protecting heart cells in various cardiovascular diseases and age-related changes. The revealed effects are of great importance for the development of approaches to designing a new type of cardioprotective compounds, activators of the transcription factor Nrf2.</p>

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Potential of Antioxidant and Cardioprotective Activity of a New Pyridoxine and Fumaric Acid Derivative as an Inductor of Transcription Factor Nrf2

  • 期刊论文

  • 发表日期：

    2026年2月1日

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  • A. A. Balakina,
  • A. D. Podgurskaya,
  • V. A. Mumyatova,
  • T. S. Stupina,
  • T. R. Prikhodchenko,
  • O. S. Suvorova,
  • S. V. Blokhina,
  • S. Ya. Gadomsky,
  • D. V. Mishchenko

摘要

The aim of the study was to evaluate the biological activity of a new type of cardioprotectors, activators of Nrf2, based on pyridoxine and fumaric acid derivatives in vitro and in vivo. It was found that di(3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridinium) fumarate is an effective activator of Nrf2 transcription factor and exhibits cytoprotective and antioxidant activity in vitro on a cardiomyocyte model. In addition, this compound reduces the cardiotoxic effect of doxorubicin in vivo by suppressing the development of oxidative processes and activating the Nrf2-dependent antioxidant response in the heart. The studied pyridoxine and fumaric acid derivative has high potential as a candidate medication for reducing the side effects of anthracycline antibiotics, as well as for protecting heart cells in various cardiovascular diseases and age-related changes. The revealed effects are of great importance for the development of approaches to designing a new type of cardioprotective compounds, activators of the transcription factor Nrf2.