<p>We studied the effect of peat smoke intoxication in pregnant rats on the early postnatal development of the second-generation offspring. The smoke was inhaled on days 14-18 of pregnancy. The first-generation offspring at puberty (3 months) was mated to produce the second-generation offspring in the following 3 variants: females exposed to prenatal smoke and intact males (experiment 1), males exposed to prenatal smoke and intact females (experiment 2), and males and females exposed to prenatal smoke (experiment 3); intact females and males comprised the control group. In the second-generation offspring, physical development, body weight gain dynamics, rate of maturation of sensorimotor reflexes, and parameters of open-field behavior were assessed. The results showed that exposure to peat smoke in pregnant rats reduced survival rates and impaired physical development in the second-generation offspring.</p>