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<p>Primary screening of the sera from aging Wistar rats and animals with high-grade gliomas was performed using the following cell lines: Gasser’s node neuroma (NGUK, trigeminal schwannoma) and high-grade glioma 11-9-2. Targeted analysis of the transcripts of the marker genes <i>S100b</i> (involved in nervous system homeostasis and damage), <i>Sox2</i> (stemness marker), and <i>Mki67</i> (proliferation marker), along with mitotic cell counting revealed statistically significant differences in transcriptional activity between the groups. This initial assessment of the sensitivity of cell lines to sera from animals with CNS pathology indicates its potential for further detailed development as a biosensor test system.</p>

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Tumor Cell Lines as a Biosensor Substrate for Pathological Aging and CNS Tumors

  • 期刊论文

  • 发表日期：

    2026年2月1日

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  • V. V. Kudelkina,
  • A. M. Kosyreva,
  • E. A. Miroshnichenko

摘要

Primary screening of the sera from aging Wistar rats and animals with high-grade gliomas was performed using the following cell lines: Gasser’s node neuroma (NGUK, trigeminal schwannoma) and high-grade glioma 11-9-2. Targeted analysis of the transcripts of the marker genes S100b (involved in nervous system homeostasis and damage), Sox2 (stemness marker), and Mki67 (proliferation marker), along with mitotic cell counting revealed statistically significant differences in transcriptional activity between the groups. This initial assessment of the sensitivity of cell lines to sera from animals with CNS pathology indicates its potential for further detailed development as a biosensor test system.