Scholarlink

<p>To assess functional characteristics of cells of the neurovascular unit in Alzheimer’s disease (AD), we performed differentiation of induced pluripotent stem cells from an AD patient (Alz9L cell line) into neuronal, glial, and endothelial cells with the formation of a three-cell model of the blood–brain barrier (BBB). Increased BBB permeability combined with changes in synaptic plasticity of neurons and changes in the metabolism of endothelial cells was detected in AD. The obtained results confirm the presence of vascular dysfunction during AD development and indicate the possibility of using personalized BBB models to assess the features of barrier formation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Application of a Three-Cell Blood–Brain Barrier Model to Assess Neurovascular Unit Cell Damage in Alzheimer’s Disease

  • 期刊论文

  • 发表日期：

    2026年2月1日

查看全文
  • N. A. Rozanova,
  • A. S. Averchuk,
  • M. R. Kapkaeva,
  • V. I. Zhdankina,
  • V. I. Makarov,
  • A. S. Skobeltsin,
  • I. D. Romanishkin,
  • T. I. Baranich,
  • A. B. Salmina

摘要

To assess functional characteristics of cells of the neurovascular unit in Alzheimer’s disease (AD), we performed differentiation of induced pluripotent stem cells from an AD patient (Alz9L cell line) into neuronal, glial, and endothelial cells with the formation of a three-cell model of the blood–brain barrier (BBB). Increased BBB permeability combined with changes in synaptic plasticity of neurons and changes in the metabolism of endothelial cells was detected in AD. The obtained results confirm the presence of vascular dysfunction during AD development and indicate the possibility of using personalized BBB models to assess the features of barrier formation.