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<p>We analyzed physicochemical properties and antigenic activity of cell envelope preparations isolated from urea lysates of different <i>Francisella tularensis</i> subspecies. Lysis of <i>F. tularensis</i> cells with a urea solution yielded polyepitopic immunogenic complexes with high antigenic activity detected in specific immunochemical reactions (dot immunoassay, immunoblotting, radial immunodiffusion) with IgG isolated from commercial horse tularemia serum and labeled with colloidal silver nanoparticles.</p>

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Physicochemical and Antigenic Properties of Experimental Preparations of Francisella tularensis

  • 期刊论文

  • 发表日期：

    2026年1月1日

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  • A. V. Korneva,
  • V. B. Nikolaev,
  • E. Y. Markov,
  • A. A. Doroshchenko,
  • Yu. O. Popova,
  • A. V. Mazepa,
  • I. V. Tikhonova,
  • K. V. Naumova,
  • N. M. Andreevskaya,
  • V. I. Dubrovina

摘要

We analyzed physicochemical properties and antigenic activity of cell envelope preparations isolated from urea lysates of different Francisella tularensis subspecies. Lysis of F. tularensis cells with a urea solution yielded polyepitopic immunogenic complexes with high antigenic activity detected in specific immunochemical reactions (dot immunoassay, immunoblotting, radial immunodiffusion) with IgG isolated from commercial horse tularemia serum and labeled with colloidal silver nanoparticles.