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<p>The content of E- and N-cadherins, components of cell–cell interactions and markers of epithelial–mesenchymal transition was assessed by Western blotting in the kidneys of <i>db/db</i> mice (a model of type 2 diabetes mellitus). Lower E-cadherin and higher N-cadherin expression were observed in the renal cortex and medulla of <i>db/db</i> mice receiving a placebo in comparison with the control <i>db/+</i> mice (<i>p</i> &lt; 0.05). These changes were associated with tubular atrophy. Animals treated with sodium/glucose co-transporter 2 (SGLT2) inhibitor empagliflozin were characterized by higher E-cadherin and lower N-cadherin expression in the renal cortex and medulla in comparison with the placebo group (<i>p</i> &lt; 0.05). The results demonstrate an association between the effect of SGLT2 inhibitor and less pronounced changes in cadherin expression in a model of diabetic kidney disease.</p>

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Empagliflozin Alleviates Changes in Renal Expression of E- and N-Cadherins in Mice with Type 2 Diabetes Mellitus

  • 期刊论文

  • 发表日期：

    2026年1月1日

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  • A. I. Korbut,
  • E. A. Ananishnikova,
  • N. P. Bgatova,
  • N. A. Muraleva,
  • V. V. Klimontov

摘要

The content of E- and N-cadherins, components of cell–cell interactions and markers of epithelial–mesenchymal transition was assessed by Western blotting in the kidneys of db/db mice (a model of type 2 diabetes mellitus). Lower E-cadherin and higher N-cadherin expression were observed in the renal cortex and medulla of db/db mice receiving a placebo in comparison with the control db/+ mice (p < 0.05). These changes were associated with tubular atrophy. Animals treated with sodium/glucose co-transporter 2 (SGLT2) inhibitor empagliflozin were characterized by higher E-cadherin and lower N-cadherin expression in the renal cortex and medulla in comparison with the placebo group (p < 0.05). The results demonstrate an association between the effect of SGLT2 inhibitor and less pronounced changes in cadherin expression in a model of diabetic kidney disease.