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<p>Using high-cancer CBA mice we showed that regulation of the expression of β2 leukocyte integrins LFA-1 and Mac-1 on peripheral blood cells, serum levels of IL-6 and IL-10, and number of dopaminergic neurons in combination with CD8<sup>+</sup> lymphocyte infiltration of the tumor and destruction of tumor nodes after preventive administration of a multiphytoadaptogen during the early ontogeny substantially affects the incidence and size of spontaneous hepatocarcinomas and increases the duration and quality of life.</p>

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Spontaneous Carcinoogenesis: Regulation of Adhesion Disorders and Cancer Prevention

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • E. V. Bocharov,
  • R. V. Karpova,
  • V. G. Kucheryanu,
  • I. V. Kazeev,
  • A. A. Aksyonov,
  • N. E. Kushlinskii,
  • I. S. Stilidi,
  • O. A. Bocharova

摘要

Using high-cancer CBA mice we showed that regulation of the expression of β2 leukocyte integrins LFA-1 and Mac-1 on peripheral blood cells, serum levels of IL-6 and IL-10, and number of dopaminergic neurons in combination with CD8+ lymphocyte infiltration of the tumor and destruction of tumor nodes after preventive administration of a multiphytoadaptogen during the early ontogeny substantially affects the incidence and size of spontaneous hepatocarcinomas and increases the duration and quality of life.