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<p>Outbred male Wistar rats underwent coronary artery occlusion (45 min) followed by reperfusion (120 min), and the infarct size to area at risk (IS/AAR) ratio was determined. For 8 days prior to coronary occlusion, rats were subcutaneously administered octreotide at doses of 20 and 40 μg/kg. In the control group rats, the levels of endogenous somatostatin were measured before occlusion and at the 120th minute of reperfusion. Preventive administration of 40 μg/kg octreotide reduced the levels of creatine kinase-MB (CK-MB) and infarct size by decreasing the necrosis area. Octreotide at a dose of 20 μg/kg produced no infarct-limiting effect. Control animals exhibited increased endogenous somatostatin levels by the end of reperfusion (in comparison with baseline), which negatively correlated with CK-MB levels.</p>

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Dynamics of Endogenous Somatostatin and the Infarct-Limiting Effect of Octreotide in a Rat Model of Long-Term Ischemia/Reperfusion

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • J. N. Ilyushenkova,
  • A. V. Mukhomedzyanov,
  • B. K. Kurbatov,
  • A. S. Slidnevskaya,
  • Yu. V. Varlamova,
  • S. I. Sazonova

摘要

Outbred male Wistar rats underwent coronary artery occlusion (45 min) followed by reperfusion (120 min), and the infarct size to area at risk (IS/AAR) ratio was determined. For 8 days prior to coronary occlusion, rats were subcutaneously administered octreotide at doses of 20 and 40 μg/kg. In the control group rats, the levels of endogenous somatostatin were measured before occlusion and at the 120th minute of reperfusion. Preventive administration of 40 μg/kg octreotide reduced the levels of creatine kinase-MB (CK-MB) and infarct size by decreasing the necrosis area. Octreotide at a dose of 20 μg/kg produced no infarct-limiting effect. Control animals exhibited increased endogenous somatostatin levels by the end of reperfusion (in comparison with baseline), which negatively correlated with CK-MB levels.