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<p>Intranasal administration of the neurotoxic fragment of β-amyloid protein Aβ25-35 for 14 days to aged C57Bl/6 mice induces impairment of passive avoidance conditioning and reduces the content of IL-10 in the prefrontal cortex and hippocampus without changing the content of IL-4 in these brain structures. Co-administration of Aβ25-35 with anti-glutamate antibodies reversed spatial memory impairment, restores the levels of IL-10, and reduces the content of IL-4 in the prefrontal cortex and hippocampus of aged C57Bl/6 mice.</p>

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Effect of Anti-Glutamate Antibodies on the Content of IL-4 and IL-10 in Brain Structures in Aged Mice with Induced Memory Impairment

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • T. V. Davydova,
  • L. A. Vetrile,
  • I. A. Zakharova

摘要

Intranasal administration of the neurotoxic fragment of β-amyloid protein Aβ25-35 for 14 days to aged C57Bl/6 mice induces impairment of passive avoidance conditioning and reduces the content of IL-10 in the prefrontal cortex and hippocampus without changing the content of IL-4 in these brain structures. Co-administration of Aβ25-35 with anti-glutamate antibodies reversed spatial memory impairment, restores the levels of IL-10, and reduces the content of IL-4 in the prefrontal cortex and hippocampus of aged C57Bl/6 mice.