<p>The dynamics of protein oxidative modification, superoxide dismutase (SOD) activity, and reduced glutathione levels were studied in the control and prenatally-stressed male rats following immobilization stress. The control group consisted of intact males not exposed to prenatal stress. Prenatal stress was modeled by immobilizing pregnant rats for 1 h per day on gestational days 15-19. Male offspring (3-months-old) were subjected to a 20 min immobilization stress. In both groups, the specified parameters were assessed at baseline (no stress), immediately after stress, and after 1, 3, and 24 h of post-stress. Prenatal stress attenuated the reactivity of these redox indicators, whereas control animals exhibited pronounced pro- and antioxidant responses following immobilization. These findings suggest that prenatal stress impairs the adaptive capacity of the redox system in adult offspring.</p>