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<p>According to current knowledge, hypoxia is a key mechanism mediating the detrimental effects of prenatal alcohol exposure on the nervous tissue. However, comparative analysis of these interrelated conditions has only been partially addressed. We conducted a morphometric analysis of fetal brain tissue affected by chronic alcohol exposure and hypoxia. A decrease in the specific area of neuroblasts, glioblasts, and microvascular elements was found. Hypoxia promoted enlargement of neuroblasts and their differentiation into immature neurons, whereas alcohol exposure led only to a decrease in their number. In the brain subjected to hypoxia, glioblasts were characterized by size variability with a general trend toward reduction, while alcohol had no significant effect on their size. Both experimental groups showed a decline in vascular density.</p>

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Comparative Characteristics of Morphometric Changes in the Brain Tissue Caused by Prenatal Alcohol Exposure and Hypoxia

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • S. N. Shumilova,
  • A. V. Solonsky,
  • A. V. Potapov,
  • S. V. Logvinov,
  • N. A. Bokhan,
  • A. I. Mandel,
  • A. Sh. Makhmutkhodzhaev,
  • E. Y. Varakuta,
  • L. R. Mustafina,
  • A. A. Zhdankina,
  • A. V. Gerasimov,
  • V. P. Kostyuchenko,
  • K. Y. Maksimova,
  • E. Y. Bulatskaya

摘要

According to current knowledge, hypoxia is a key mechanism mediating the detrimental effects of prenatal alcohol exposure on the nervous tissue. However, comparative analysis of these interrelated conditions has only been partially addressed. We conducted a morphometric analysis of fetal brain tissue affected by chronic alcohol exposure and hypoxia. A decrease in the specific area of neuroblasts, glioblasts, and microvascular elements was found. Hypoxia promoted enlargement of neuroblasts and their differentiation into immature neurons, whereas alcohol exposure led only to a decrease in their number. In the brain subjected to hypoxia, glioblasts were characterized by size variability with a general trend toward reduction, while alcohol had no significant effect on their size. Both experimental groups showed a decline in vascular density.