Scholarlink

<p>The antimicrobial activity of <i>Escherichia</i> phage Ec1-7 and <i>Escherichia</i> phage Ec2-7 was evaluated both separately and in a phage cocktail. The combination of phages significantly extended the spectrum of lytic activity and effectively inhibited the growth of bacteria, including strains with emerging resistance. The phage cocktail exhibited higher efficacy (3.6-4.8 lg(CFU/ml)) in comparison with monophages (1.3-2.8 lg(CFU/ml)) during a 6-h incubation period: it prevented secondary bacterial growth and reduced the likelihood of resistance development. Our findings corroborate the potential of phage cocktails in combating antibiotic-resistant strains.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A Rational Approach to Developing a Phage Biopreparation: Boosting Lytic Efficiency and Countering Resistance in Pathogenic Escherichia coli

  • 期刊论文

  • 发表日期：

    2025年10月1日

查看全文
  • E. R. Zulkarneev,
  • N. V. Pimenov,
  • A. S. Tishchenko,
  • T. A. Kapustina,
  • S. V. Pozyabin

摘要

The antimicrobial activity of Escherichia phage Ec1-7 and Escherichia phage Ec2-7 was evaluated both separately and in a phage cocktail. The combination of phages significantly extended the spectrum of lytic activity and effectively inhibited the growth of bacteria, including strains with emerging resistance. The phage cocktail exhibited higher efficacy (3.6-4.8 lg(CFU/ml)) in comparison with monophages (1.3-2.8 lg(CFU/ml)) during a 6-h incubation period: it prevented secondary bacterial growth and reduced the likelihood of resistance development. Our findings corroborate the potential of phage cocktails in combating antibiotic-resistant strains.