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<p>The composition of mucosa-associated microbiota of the colon of experimental animals was studied under conditions of chronic restraint stress of varying duration (14 and 28 days). Identification and quantitative assessment of microorganisms was carried out by mass spectrometry of microbial markers. Stress has a pronounced inhibitory effect on most non-spore-forming anaerobes, facultative anaerobic and aerobic bacteria, and actinomycetes, promotes the growth and reproduction of <i>Candida</i> fungi and <i>Clostridium difficile</i>. Enterococci, staphylococci, and lactobacilli exhibit adaptive properties under stress for 28 days, bifidobacteria are most sensitive to restraint stress.</p>

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Effect of Chronic Restraint Stress on the Composition of Mucosa-Associated Microbiota of Rat Colon

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • E. S. Vorsina,
  • O. A. Medvedeva,
  • I. I. Bobyntsev,
  • A. O. Vorvul

摘要

The composition of mucosa-associated microbiota of the colon of experimental animals was studied under conditions of chronic restraint stress of varying duration (14 and 28 days). Identification and quantitative assessment of microorganisms was carried out by mass spectrometry of microbial markers. Stress has a pronounced inhibitory effect on most non-spore-forming anaerobes, facultative anaerobic and aerobic bacteria, and actinomycetes, promotes the growth and reproduction of Candida fungi and Clostridium difficile. Enterococci, staphylococci, and lactobacilli exhibit adaptive properties under stress for 28 days, bifidobacteria are most sensitive to restraint stress.